Faculty

Xiaohong HUOProfessor

Email: huoxiaohong@sjtu.edu.cn 
Address: 上海市东川路800号太阳成集团tyc7111ccB楼529室 
Home Page: http://wanbin.sjtu.edu.cn/ 

Educational Background


EDUCATION
2012-2017 Shanghai Jiao Tong University, Ph.D. Advisor: Prof. Wanbin Zhang
2013-2013 Tohoku University, Exchange Student (Campus Asia Program)
2012-2017 Shanghai Jiao Tong University, M.S. Advisor: Prof. Wanbin Zhang
2012-2017 Henan University (HNU), B.S.


Work Experience

2017-2019 上海交通大学,博士后(合作导师:张万斌 讲席教授)
2019-至今 太阳成集团tyc7111cc,长聘教轨副教授,博士生导师

Research Interests

RESEARCH INTERESTS
My research focused on developing synergistic catalysis strategy to improve or develop the reactions from the viewpoint of reactivity, efficiency, and selectivity. And then we applied these strategies for the effective synthesis of the bioactive molecules.

Research Project

主持国家自然科学基金面上项目、青年科学基金项目、上海市“科技创新行动计划”青年科技英才扬帆计划、中国博士后科学基金面上项目一等资助,作为科研骨干参与国家自然科学基金重点、国际(地区)合作和面上项目、上海市科委和教委重大和重点科技攻关项目等多项课题研究。

Publications

2020

(1) Rui He,§ Xiaohong Huo,§ Ling Zhao, Feijun Wang, Liyin Jiang, Jian Liao,* and Wanbin Zhang*, "Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates", J. Am. Chem. Soc., 2020, 142, in press. (§co-first author)


(2) Guanlin Li,§ Xiaohong Huo,§ Xieyang Jiang, and Wanbin Zhang*, "Asymmetric Synthesis of Allylic Compounds via Hydrofunctionalisation and Difunctionalisation of Dienes, Allenes, and Alkynes", Chem. Soc. Rev., 2020, 49, 2060-2118. Inside front cover (§co-first author)


(3) Yue Wu, Xiaohong Huo*, and Wanbin Zhang*, "Synergistic Pd/Cu Catalysis in Organic Synthesis", Chem. Eur. J., 2020, 26, 4895-4916. Invited Review

 

2019

(1) Jiacheng Zhang,§ Xiaohong Huo,§ Bowen Li, Zhouli Chen, Yashi Zou, Zhenliang Sun*, and Wanbin Zhang*, "Enantioselective and Diastereodivergent Access to α-Substituted α-Amino Acids via Dual Iridium and Copper Catalysis", Adv. Synth. Catal., 2019, 361, 1130-1139. (§co-first author)


(2) Xiaohong Huo, Rui He, and Wanbin Zhang*, "Iridium/Zinc and Iridium/Copper Dual Catalysis" in SOS Reference Library: Dual Catalysis in Organic Synthesis; Gary A. Molander Ed.; 2019, accepted. Georg Thieme Verlag KG, A Thieme Group company, RuedigerstraBe 14, 70469 Stuttgart, Germany.


2019年之前

Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He, and Wanbin Zhang*, Ir/Cu Dual Catalysis: "Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters", J. Am. Chem. Soc., 2018, 140, 2080-2084. (ESI Highly Cited Paper)


Penglin Liu,§ Xiaohong Huo,§ Bowen Li, Rui He, Jiacheng Zhang, Tianhong Wang, Fang Xie*, and Wanbin Zhang*, "Stereoselective Allylic Alkylation of 1-Pyrroline-5-carboxylic Esters via a Pd/Cu Dual Catalysis", Org. Lett., 2018, 20, 6564-6568. (§co-first author)


Xiaohong Huo,§ Jingke Fu,§ Xiaobo He, Jianzhong Chen, Fang Xie, and Wanbin Zhang*, "Pd/Cu Dual Catalysis: Highly Enantioselective Access to α-Substituted α-Amino Acids and α-Amino Amides", Chem. Commun., 2018, 54, 599-602. (§co-first author)



Xiaohong Huo, Rui He, Jingke Fu, Jiacheng Zhang, Guoqiang Yang, and Wanbin Zhang*, "Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis", J. Am. Chem. Soc., 2017, 139, 9819-9822. (ESI Highly Cited Paper)


Jingke Fu, Xiaohong Huo, Bowen Li, and Wanbin Zhang*, "Cooperative bimetallic catalysis in asymmetric allylic substitution", Org. Biomol. Chem., 2017, 15, 9747-9759. Invited Review

 

Jiangyan Jing, Xiaohong Huo, Jiefeng Shen*, Jingke Fu, Qinghua Meng*, and Wanbin Zhang*, "Direct Use of Allylic Alcohols and Allylic Amines in Palladium-Catalyzed Allylic Amination", Chem. Commun., 2017, 53, 5151-5154.


Xiaohong Huo,§ Rui He,§ Xiao Zhang, and Wanbin Zhang*, "An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones", J. Am. Chem. Soc., 2016, 138, 11093-11096. (ESI Highly Cited Paper) (§co-first author)


Haoming Tang, Xiaohong Huo, Qinghua Meng*, and Wanbin Zhang*, "The Palladium-Catalyzed Allylic C-H Functionalization: The Development of New Catalytic Systems", Acta Chimica Sinica, 2016, 74, 219-233.


Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, "Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study", Angew. Chem. Int. Ed., 2014, 53, 6776-6780.


Xiaohong Huo, Mao Quan, Guoqiang Yang, Xiaohu Zhao, Delong Liu*, Yangang Liu, and Wanbin Zhang*, "Hydrogen-Bond-Activated Palladium-Catalyzed Allylic Alkylation via Allylic Alkyl Ethers: Challenging Leaving Groups", Org. Lett. 2014, 16, 1570-1573.






   


Software Copyright Reqistration and Patent

1. 发明人: 张万斌、何睿、张晓、霍小红;
发明名称: 3-取代的3-乙烯基-2-羟基-1-芳基丙酮及其合成方法;
申请日: 2016.08.16; 授权公告日: 2020.09.15;
授权公告号: CN106316813B;
授权专利号:
ZL 2016 1 0674646.7

2. 发明人: 张万斌、王沫、张露、霍小红、张振锋、袁乾家、陈建中;
发明名称: 一种磷手性核苷衍生物的不对称催化合成方法及催化剂;
专利申请日: 2020.6.3; 授权公告日: 2022.9.9;
专利号: CN202010495819.5

3. 发明人: 张万斌、陈建中、张露、袁乾家、霍小红、张振锋;
发明名称: 一种不对称催化无保护基核苷合成瑞德西韦的方法;
专利申请日: 2020.6.3; 授权公告日: 2022.10.25;
专利号: CN202010495820.8

Honors and Awards

1)2014年上海交通大学三好学生

2)2014年博士生国家奖学金

3)2016年上海交通大学药学院“科技创新先进个人”

4)2016年美国化学会上海分会研究生学术成就奖二等奖

5)2016年上海交通大学第一届学术之星(共10名)

6)2018年上海交通大学博士后考核优秀

7)2018年上海交通大学优秀博士学位论文奖(共13名,作为唯一博士毕业生代表发言)

8)2019年上海市“科技创新行动计划”青年科技英才扬帆计划
9)2020年上海市自然科学奖一等奖(第三完成人)

10)2022年上海交通大学第二届“十大科技进展”

11)第十七届“挑战杯”特等奖指导专家

12)国家“万人计划”青年拔尖人才

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